李三华个人简历

李三华，女，副教授，硕士研究生导师。主要从事中药活性物质防治老年性疾病和抗肿瘤研究；近5年主持国家科学基金项目1项，完成地厅级项目2项，发表研究论文10余篇。

研究项目：

1． 国家自然科学基金项目，华蟾素活性物质嚏根草配基通过SLC7A11诱导铁死亡抑制结肠癌生长的分子机制研究，2023-2026，在研，主持。

2． 遵义市科技局基金项目，蟾皮活性成分“3-表-蟾毒它灵”体内外抗结肠癌活性的研究，2018-2021，结题，主持。

3． 贵州省卫健委基金项目，知母皂苷AIII联合Raf/MEK/ERK信号通路抑制剂类药物抗肝癌增效的研究，2017-2019，结题，主持。

部分研究论文：

1. Nian Jiang^#,Sanhua Li^#, Lingjie Meng, Yao Zhang, Changyan Yu,Yi Xiao, Yun Liu.Gamabufotalin inhibits colitis-associated colorectal cancer by suppressing transcription factor STAT3. European Journal of Pharmacology, 2024, DOI: 10.1016/j.ejphar.2024.176372.

2. Sanhua Li, Qinhong Kong, Xiaoke Zhang, Xinting Zhu, Chunbo Yu,Changyan Yu, Nian Jiang, Jing Hui, Lingjie Meng, Yun Liu. 3-epi-bufotalin suppresses the proliferation in colorectal cancer cells through the inhibition of the JAK1/STAT3 signaling pathway. BIOCELL, 2022,46(11): 2425-2432.

3. Feng Pan^#,Sanhua Li^#, Xinting Zhu, Jianbo Yang, Jing Wen, Changwei Song, Xirong Luo, Guoyong Ruan, Yun LIiu.Purification and the effects on structure and bioactivity for polysaccharide from Actinidia valvata Dunn. using macroporous adsorption resin. Food Science and Technology, 2022,DOI:https://doi.org/10.1590/fst.99721.

4. Nian Jiang, Changyan Yu, Jing Hui, Jianxun Xie, Yuanyuan Wang , Jun Yang ,Sanhua Li *, Lingjie Meng*.Chemical constituents from Maytenus hookeri. Biochemical Systematics and Ecology, 2022, DOI: https://doi.org/10.1016/j.bse.2022.104475.

5. Chunjiao Liu, Qinhong Kong, Feng Pan, Shan Jiang, Lingjie Meng, Gai Huang, LidanLu,Sanhua Li*,Yun Liu*.Hellebrigenin inducesapoptosis in colorectal cancer Cells through induction of excessive reactive oxygen species. BIOCELL，2021 45(4): 943-951.

6.Yi Xiao, Qiang Gong,Wenhong Wang, Fang Liu, Qinghong Kong, Feng Pan, Xiaoke Zhang, Changyan Yu, Shanshan Hu, Fang Fan,Sanhua Li*,Yun Liu*.The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma. Cancer Cell International, 2020, 20(1):371.