刘云，博士，教授，硕士生导师，贵州省教育厅科技拔尖人才，贵州省高层次创新型人才（千层次），中国药理学会抗炎免疫药理专委会青年委员，贵州省药学会青年专业委员会副主任委员。主要从事肿瘤生物标志物及新药创制方面的研究工作，擅于利用多学科交叉的方法挖掘具有成药潜力的小分子化合物。先后主持国家自然科学基金，贵州省社会发展攻关项目，贵州省科学技术基金等各级课题10项。近五年，以第一或通讯作者(含共同)在Nanoscale Horizons，Virulence，Cancer Cell International等杂志上发表SCI收录论文共14篇。

 

 

 

近年来主持的主要科研项目

1. 去甲基斑蝥素酸镁抗肝癌活性的分子机制研究，国家自然科学基金，81660611，2017-2020。

2. 专利化合物—去甲基斑蝥素酸镁抗肝癌活性关键应答基因的挖掘与研究，贵州省科技计划项目，黔科合基础[2019]1346号，2019-2021。

3. 贵州省普通高等学校科技拔尖人才支持计划，贵州省教育厅，黔教合KY字[2018]055，2018-2021。

近年来发表的代表性论文

1. Yi Xiao^#, Qiang Gong^#, Wenhong Wang^#, Fang Liu, Qinghong Kong, Feng Pan, Xiaoke Zhang, Changyan Yu, Shanshan Hu, Fang Fan, Sanhua Li* and Yun Liu*. The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma[J]. Cancer Cell International,2020,20:371（IF: 4.175）

2. Jinghua Li^#, Yun Liu^#, Xiaonan Li, Gaofeng Liang, Changshun Ruan* and Kaiyong Cai*，ROS self-generation and hypoxia self-enhanced biodegradable magnetic nanotheranostics for targeted tumor therapy[J]. Nanoscale Horizons, 2020,5(2):350-358.（IF: 9.927）

3. Yi Xiao^#, Fang Liu^#, Sanhua Li, Nian Jiang, Changyan Yu, Xinting Zhu, Ying Qin, Jing Hui, Lingjie Meng, Changwei Song, Xiaofei Li*, Yun Liu*. Metformin promotes innate immunity through a conserved PMK-1/p38 MAPK pathway[J]. Virulence, 2020,11(1):39-48.（IF: 5.542）

4. Changwei Song, Changyan Yu, Xinting Zhu, Xirong Luo, Yong Zhang, Lingjie Meng, Yong Luo, Chang Han, Cheng Qin, and Yun Liu*. A new N-containing phenolic glycoside from Capsicum annuum L.[J]. Natural Product Research, 2020. Doi: 10.1080/14786419.2020.1789983.（IF: 2.158）

5. Lingjie Meng, Sanhua Li, Qinghong Kong, Mei Wang, Xiaoke Zhang, Xinting Zhu, Wei Yu, Nian Jiang, , Zeli Chun, Nian Li, Yun Liu*. Two new 19-hydroxy bufadienolides with cytotoxic activity from the skins of Bufo melanosticus[J]. Natural Product Research, 2020(5):1-7.（IF: 2.158）

6. Wenhong Wang, Yi Xiao, Sanhua Li, Xinting Zhu, Lingjie Meng, Changwei Song, Changyan Yu, Nian Jiang, Yun Liu*, Synergistic activity of magnolin combined with B-RAF inhibitor SB590885 in hepatocellular carcinoma cells via targeting PI3K-AKT/mTOR and ERK MAPK pathway[J]. American Journal of Translational Research, 2019,11(6):3816-3824.（IF: 3.375）

7. Meng Ye, Xinting Zhu, Rong Yan, Jing Hui, Jiangyong Zhang,Yun Liu*, Xiaofei Li*. Sodium demethylcantharidate induces apoptosis in hepatocellular carcinoma cells via ER stress[J]. American Journal of Translational Research, 2019,11(5):3150. （IF: 3.375）