徐林,男,博士,博士后,教授,博士研究生导师。美国免疫学会会员、中国免疫学会理事、贵州省免疫学会副理事长。教育部新世纪优秀人才、贵州省百层次创新型人才、省管专家、省政府津贴专家。贵州省基础医学特色重点学科带头人、贵州省肿瘤微小RNA的基础与应用研究科技创新人才团队领衔人、国家自然科学基金重大项目和面上项目网评专家。主要从事肿瘤免疫逃逸和干预领域研究。主持国家自然科学基金4项,贵州省科技厅课题4项,第一作者或通讯作者发表文章108篇,SCI收录40篇,其中IF>3.0论文24篇,IF>7.0论文3篇,总期刊影响因子152.3,被引用超过1000次。以第1完成人获得贵州省科技进步二等奖2项,省医学科技奖一等奖2项,遵义医学院科技一等奖1项。
研究项目:
1. 微小RNA-7对CD4+T细胞功能的调控作用及机制研究,国家自然科学基金(31760258),201801-202112,主持。
2. 乳腺癌中CCR6+调节性T细胞特征miRNAs分子的表达及其功能鉴定,国家自然科学基金(81260398),201301-201612,主持。
3. 诱导性Foxp3+调节性T细胞相关特征miRNA对其抑制功能维持的作用研究,国家自然科学基金(31370918),201401-201712,主持。
4. miRNA-126对CD4+CD25+调节性T细胞外周诱导的作用研究,国家自然科学基金(30901318),200901-201212,主持。
学术论文:
1.Zhao J, Zhou Y, Guo M, Yue D, Chen C, Liang G, Xu L*. MicroRNA-7: expression and function in brain physiological and pathological processes. Cell Biosci, 2020.10:77.
2.Yue D, Zhao J, Chen H, Guo M, Chen C, Zhou Y, Xu L*. MiRNA-7, synergizes with RORα, negatively controls the pathology of Brain Tissue Inflammatory. J Neuroinfla, 2020.17(1):28.
3.Din T, Zhou Y, Long R, Chen C, Zhao J, Cui P, Guo M, Liang G, Xu L*. DUSP8 Phosphatase: Structure, Functions, Expression Regulation and the Role in Human Diseases. Cell Biosci, 2019. 9:70.
4.Ding T, Cui P, Zhou Y, Chen C, Zhao J, Wang H, Guo M, He Z, Xu L*. Antisense oligonucleotides against microRNA-21 inhibited the growth and metastasis of colorectal carcinoma cells via DUSP8 pathway. Mol Ther Neucli ACIDS. 2018. 13:244-255. **
5.Jia L, Lu J, Zhou Y, Tao Y, Xu H, Zheng W, Zhao J, Liang G, Xu L*. Tolerogenic dendritic cells induced the enrichment of CD4+Foxp3+ regulatory T cells via TGF-β in mesenteric lymph nodes of murine LPS-induced tolerance model. Clin Immunol. 2018;197:118-129. **
6.Chen C, Yue D, Lei L, Wang H, Jia L, Zhou Y, Liu S, Ding T, Guo M, Xu L*. Promoter-operating Targeted expression of Gene therapy in cancer: current stage and prospect. Mol Ther Neucli ACIDS. 2018, 11(6):508-514.
7.Lei L, Chen C, Zhao J, Wang H, Guo M, Zhou Y, Luo J, Zhang J, Xu L*. Targeted expression of miR-7 operated by TTF-1 promoter inhibited the growth of human lung cancer through NDUFA4 pathway. Mol Ther Nucleic Acids, 2017, 6(3):183-197.**
8.Zhao J, Chen C, Guo M, Tao Y, Cui P, Zhou Y, Qin N, Zheng J, Zhang J, Xu L*. MicroRNA-7 deficiency ameliorates the pathologies of Acute Lung Injury through Elevating KLF4. Front Immunol, 2016. 7:389. **
9.Qin A, Wen Z, Zhou Y, Li Y, Li Y, Luo J, Ren T, Xu L*. MicroRNA-126 regulates the induction and function of CD4+ Foxp3+ regulatory T cells through PI3K/AKT pathway. J Cell Mol Med. 2013; 17(2):252-64. **
10.Guo ZL, Wen ZK, Qin AD, Zhou Y, Ren T, Xu L*. Antisense oligonucleotides treatment enhanced the recovery of acute lung injury through IL-10 secreting M2 like macrophages-induced expansion of CD4+ regulatory T cells. J Immunol, 2013,190(8):4337-48. **