于红松,男,博士,中共党员,免疫学教授,博士生导师,基础医学院科技与研究生科科长;是国家科技进步二等奖获得者,贵州省千人创新创业人才,贵州省最美劳动者,贵州省普通高等学校科技拔尖人才,遵义医科大学青年领军人才,遵义市高校优秀科技工作者,遵义市五一劳动奖章获得者,国家自然科学基金通讯评审专家,遵义医科大学优秀青年工作者;任贵州省免疫学会理事、贵州省菌物学会理事、《遵义医科大学学报》青年编委等学术职务;是Thyroid等10余份SCI杂志特邀审稿人。
从事自身免疫性甲状腺疾病和免疫性高致盲眼病的发病机制研究,主要探讨DNA甲基化、microRNA、SNP/CNV和Th17/Treg平衡在自身免疫性甲状腺疾病和免疫性高致盲眼病发生发展中的作用。主持国家自然科学基金项目3项,其中面上项目1项,青年基金项目1项,地区科学基金项目1项;主持国家重点研发计划项目子课题1项;主持贵州省科技厅重点项目1项;主持其他省部厅局级科研项目7项;以第一作者或通讯作者在J Allergy Clin Immun (IF=14.29)等杂志发表论文30余篇,以共同作者在Nat Genet等杂志参与发表论文20余篇,论文被Science等杂志正面引用900余次;参编中文专著《眼科表观遗传学》(人民卫生出版社)和英文专著《Genetic Eye Research in Asia and the Pacific》(Springer 出版社);获国家科技进步奖二等奖、省级科技进步奖一等奖和省级研究生教学成果奖二等奖各1项;积极参与国内外学术交流:曾赴美国旧金山参加第十三届国际眼炎症学会大会(IOIS);以大会发言或者专题发言的方式参与了全国免疫学学术大会、全国眼科学学术大会、中国眼科学和视觉科学研究大会、中国遗传学会大会等。
研究项目(国家级):
1. miR-182及其启动子甲基化状态在葡萄膜炎发生中的作用和机制研究,国家自然科学基金面上项目(81670844),58万元,2017.01-2020.12,主持
2. SOX9在VKH综合征黑色素脱失中的作用及分子机制研究,国家自然科学基金青年基金项目 (81200678) ,23万元,2013.01-2015.12,主持
3. 环境遗传交互作用对妊娠相关疾病作用研究,国家重点研发计划项目子课题 (2018YFC1004303) ,100.27万元,2018.12-2022.12,主持
4. miR-886-5p通过下调靶基因MINK1在Graves病发生中的作用及机制研究,国家自然科学基金地区科学基金项目 (82160154) ,34万元,2022.01-2025.12,主持
代表性学术论文:
1.Yu Hongsong#, Zheng Minming#, Zhang Lijun#, Li Hua, Zhu Yunyun, Cheng Ling, Li Lin, Deng Boling, Kijlstra Aize, Yang Peizeng*. Identification of susceptibility SNPs in IL10 and IL23R-IL12RB2 for Behçet's disease in Han Chinese. J Allergy Clin Immunol. 2017, 139(2): 621-627. (IF=14.29)
2.Yu Hong-Song, Shen Yi-Hong, Yuan Gang-Xiang, Hu Yong-Gang, Xu Hong-En, Xiang Zhong-Huai, Zhang Ze*. Evidence of selection at melanin synthesis pathway loci during silkworm domestication. Mol Biol Evol. 2011, 28(6): 1785-1799. (IF=16.24)
3.Yu Hongsong#, Du Liping#, Yi Shenglan, Wang Qingfeng, Zhu Yunyun, Qiu Yiguo,Jiang Yan, Li Minghui, Wang Detao, Wang Qing, Yuan Gangxiang, Cao Qingfeng, Kijlstra Aize, Yang Peizeng*. Epigenome-wide association study identifies Behcet's disease-associated methylation loci in Han Chinese. Rheumatology. 2019, 58(9):1574-1584. (IF=7.046)
4.Du Juan, Wang Xin, Tan Guiqin, Liang Zhongzhi, Zhang Ze, Yu Hongsong*(corresponding author).The association between genetic polymorphisms of interleukin 23 receptor gene and the risk of rheumatoid arthritis: An updated meta-analysis. Clin Immunol. 2020, 210: 108250.(IF=10.19)
5.Ma Xiaomin, Wang Xin, Zheng Guangbing, Tan Guiqin, Zhou Fangyu, Wei Wenwen, Tian Dan, Yu Hongsong*(corresponding author). Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease. Front Cell Dev Biol. 2021, 9: 719235. (IF=6.684)
6.Zhou Fangyu, Wang Xin, Wang Lingjun, Sun Xin, Tan Guiqin, Wei Wenwen, Zheng Guangbing, Ma Xiaomin, Tian Dan, Yu Hongsong*(corresponding author). Genetics, Epigenetics, Cellular Immunology, and Gut Microbiota: Emerging Links With Graves' Disease.Front Cell Dev Biol. 2022, 9: 794912. (IF=6.684)
7.Wang Yan, Ma Xiao-Min, Wang Xin, Sun Xin, Wang Ling-Jun, Li Xin-Qi, Liu Xiao-Yan, Yu Hong-Song* (corresponding author).Emerging Insights Into the Role of Epigenetics and Gut Microbiome in the Pathogenesis of Graves' Ophthalmopathy. Front Endocrinol. 2022, 12: 788535. (IF=6.050)
8. Du Juan, Wang Xin, Tan Guiqin, Wei Wenwen, Zhou Fangyu, Liang Zhongzhi, Li Hua, Yu Hongsong* (corresponding author). Predisposition to Graves' disease and Graves' ophthalmopathy by genetic variants of IL2RA. J Mol Med. 2021, 99(10): 1487-1495 (IF=5.606)
9.Wei Wenwen, Wang Xin, Zhou Yuanzhong, Shuang Xuejun, Yu Hongsong* (corresponding author). The genetic risk factors for pregnancy-induced hypertension: Evidence from genetic polymorphisms.FASEB J. 2022, 36(7): e22413.(IF=5.834)
10.Yu Hongsong, Liu Yunjia, Bai Lin, Kijlstra Aize, Yang Peizeng*. Predisposition to Behçet’s disease and VKH syndrome by genetic variants of miR-182. J Mol Med. 2014, 92(9): 961-967. (IF=5.606)
11.Yu Hongsong#, Luo Le#, Wu Lili, Zheng Minming, Zhang Lijun, Liu Yunjia, Li Hua, Cao Qingfeng, Kijlstra Aize, Yang Peizeng*. FAS gene copy numbers are associated with susceptibility to Behçet disease and VKH syndrome in Han Chinese.Hum Mutat. 2015, 36(11): 1064-1069. (IF=5.089)
12.Yu Hongsong, Liu Yunjia, Zhang Lijun, Wu Lili, Zheng Minming, Cheng Ling, Luo Le, Kijlstra Aize, Yang Peizeng*. FoxO1 gene confers genetic predisposition to acute anterior uveitis with ankylosing spondylitis. Invest Ophthalmol Vis Sci. 2014, 55(12): 7970-7974. (IF=4.925)
13. Zhou Fangyu#, Liang Zhongzhi#, Wang Xin, Tan Guiqin, Wei Wenwen, Zheng Guangbing, Ma Xiaomin, Tian Dan, Li Hua, Yu Hongsong*(corresponding author). The VDR gene confers a genetic predisposition to Graves' disease and Graves' ophthalmopathy in the Southwest Chinese Han population. Gene. 2021, 793:145750. (IF=3.913)