性 别

男

通讯地址

贵州省遵义市新蒲新区校园1号路

邮 编

563000

邮 箱

xiaoyizmu@126.com

职 称

副高，硕士生导师

简 介

中国共产党党员、博士、副高、硕士生导师。贵州省高层次创新型人才培养计划“千”层次入选者。遵义医科大学优秀教师（2023）。遵义医科大学基础医学优秀本科生指导老师。主要从事肿瘤分子生物学，天然免疫及抗衰老分子机制研究和新药研发。先后主持国家自然科学基金、贵州省科技计划重点项目等4项。近3年，以第一作者或通讯作者(含共同)在Aging Cell,Cellular and Molecular Life Sciences,Journal of Infectious Diseases,iScience,STAR Protocols, Int Immunopharmacol, Virulence等国际知名杂志上发表SCI收录论文18篇，累积影响因子破100，并被同行广泛引用（包括被发表Nature Immunology,elife,Cell Mol Biol Lett,Oncoimmunology等高水平杂志的论文所引用）。目前为Aging Cell,Journal of Advanced Research, Phytotherapy Research,Aging and Disease,iScience,STAR Protocols,Int Immunopharmacol,Oncoimmunology等20多种SCI期刊的审稿人。

教育背景

云南大学，微生物学专业，博士

主讲课程

《科研方法与实验技术》《科技论文绘图技术》

科研项目

1.国家自然科学基金，去乙酰化酶HDA-1/HDAC1通过内质网应激信号途径促进天然免疫的分子机制研究，2021.01-2024.12，34万元，主持。

2.贵州省科技计划项目（重点项目），大黄酚通过胰岛素信号途径DAF-2（IGF-1R）/DAF-16（FOXO3A）抗衰老的分子机制研究，2024.04-2028.04，30万元，主持。

3.国家自然科学基金，同源盒转录因子CEH-37/OTX2通过P38 MAPK信号途径促进天然免疫的分子机制研究，2022.01-2025.12，34万元，主研。

4.国家自然科学基金，蟾皮单体Argentinogenin通过STAT3-CPT1B介导肝癌细胞脂质代谢失衡抑制肿瘤转移的机制研究，2022.01-2025.12，34万元，主研。

发表论文

近3年部分代表性论文如下：

1.Yi Xiao^#(第一作者), Fang Liu^#, Qinghong Kong, Xinting Zhu, Haijuan Wang, Sanhua Li, Nian Jiang, Changyan Yu, Yun Liu*. Metformin induces S-adenosylmethionine restriction to extend theCaenorhabditis elegans healthspan through H3K4me3 modifiers [J].Aging Cell, 2022: e13567. (IF=11发表当年), JCR一区(一区top)。

2.Fang Liu^#, Hongjiao Zhang^#, Haijuan Wang^#, Xinting Zhu, Sanhua Li, Nian Jiang, Changyan Yu, Yun Liu*,Yi Xiao*(通讯作者). The homeodomain transcription factor CEH-37 regulates PMK-1/p38 MAPK pathway to protect against intestinal infection via the phosphatase VHP-1 [J]. Cell Mol Life Sci. 2023 Oct 5;80(11):312. (IF=8发表当年), JCR一区(一区top)。

3.Yi Xiao^#*(第一作者兼通讯作者), Fang Liu^#,Qinyi Wu^#, Xinting Zhu, Changyan Yu, Nian Jiang, Sanhua Li, Yun Liu*. Dioscin activates endoplasmic reticulum UPR for defense against pathogen bacteria in Caenorhabditis elegans via IRE-1/XBP-1 pathway [J]. Journal of Infectious Diseases, 2024 Jan 12; 229(1):237-244. (IF= 6.4发表当年), JCR一区(二区top)。

4.Yi Xiao^#*(第一作者兼通讯作者), Hanlin Zhou^#, Yingwen Cui^#, Xinting Zhu, Sanhua Li, Changyan Yu, Nian Jiang, Liu Liu*, Fang Liu*. Schisandrin A enhances pathogens resistance by targeting a conserved p38 MAPK pathway [J].Int Immunopharmacol. 2024 Jan 3;128:111472. (IF=5.7发表当年), JCR一区(二区top)。

5.Fang Liu^#, Haijuan Wang^#, Xinting Zhu^#, Nian Jiang, Feng Pan, Changwei Song, Chunbo Yu, Changyan Yu, Ying Qin, Jing Hui, Sanhua Li,Yi Xiao*(通讯作者), Yun Liu*. Sanguinarine promotes healthspan and innate immunity through a conserved mechanism of ROS-mediated PMK-1/SKN-1 activation [J]. iScience, 2022, 25(3):103874. (IF= 6.1发表当年), JCR一区(二区)。

6.Yi Xiao^#*(第一作者兼通讯作者), Li Zhang^#, Yu Liu*. Protocol for assessing the healthspan ofCaenorhabditis elegans after potential anti-aging drug treatment.STAR Protoc. 2023 May 5;4(2):102285.

7.Yi Xiao^#(第一作者), Huiling Zhang^#, Yi Sheng^#,Fang Liu, Jiajun Gao, Guosheng Liu, Sanhua Li,Nian Jiang, Changyan Yu,Yun Liu*. Usnic Acid extends healthspan and improves the neurodegeneration diseases via mTOR/PHA-4 signaling pathway inCaenorhabditis elegans [J].iScience, 2022 Nov 9;25(12):105539. (IF= 6.1发表当年), JCR一区(二区)。

8.Yi Xiao^#*(第一作者兼通讯作者), Fang Liu^#,Xinting Zhu ^#, Sanhua Li^#,Lingjie Meng, Nian Jiang, Changyan Yu, Haijuan Wang, Ying Qin, Jing Hui,Chunbo Yu,Yun Liu*. Dioscin integrates regulation of monosaturated fatty acid metabolism to extend the life span through XBP-1/SBP-1 dependent manner [J].iScience,2023 Feb 24;26(3):106265.(IF=6.1发表当年), JCR一区(二区)。

9.Yi Xiao^#(第一作者), Li Zhang^#, Xinting Zhu, Ying Qin, Changyan Yu, Nian Jiang, Sanhua Li, Fang Liu^*, Yun Liu^*. Luteolin promotes pathogen resistance inCaenorhabditis elegans via DAF-2/DAF-16 insulin-like signaling pathway [J].Int Immunopharmacol 2023;115:109679. (IF= 5.7发表当年),JCR一区(二区top)。

10. Xinting Zhu^#, Fang Liu^#, Qinyi Wu^#, Sanhua Li, Guoyong Ruan, Jianbo Yang, Changyan Yu, Nian Jiang,Yi Xiao*(通讯作者),Yun Liu*. Brevilin A enhances innate immunity and the resistance of oxidative stress inCaenorhabditis elegans via p38 MAPK pathway [J].Int Immunopharmacol2022;113:109385. (IF= 5.7发表当年),JCR一区(二区top)。

11.Yi Xiao^#(第一作者), Fang Liu^#, Sanhua Li, Nian Jiang, Changyan Yu, Xinting Zhu, Ying Qin, Jing Hui, Lingjie Meng, Changwei Song, Xiaofei Li*,Yun Liu*. Metformin promotes innate immunity through a conserved PMK-1/p38 MAPK pathway [J].Virulence, 2020, 11(1): 39-48.(IF= 5.8发表当年),JCR一区(一区top)。

12.Yi Xiao^#(第一作者), Qiang Gong^#, Wenhong Wang^#, Fang Liu, Qinghong Kong, Feng Pan, Xiaoke Zhang, Changyan Yu, Shanshan Hu, Fang Fan, Sanhua Li*,Yun Liu*. The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma [J].Cancer Cell International, 2020,20(1):371.(IF= 6.4发表当年),JCR二区(二区)。

13. Yi Xiao^#*(第一作者兼通讯作者), Chao Han^#, Xiaocong Li^#, Xinting Zhu, Sanhua Li, Nian Jiang, Changyan Yu, Yun Liu*, Fang Liu*. S-Adenosylmethionine (SAM) diet promotes innate immunity via histone H3K4me3 complex [J].Int Immunopharmacol. 2024 Mar 11;131:111837. (IF= 5.7发表当年),JCR一区(二区top)。

14. Nian Jiang^#,Sanhua Li^#, Lingjie Meng, Yao Zhang, Changyan Yu,Yi Xiao*(通讯作者),Yun Liu*. Gamabufotalin inhibits colitis-associated colorectal cancer by suppressing transcription factor STAT3 [J].Eur J Pharmacol. 2024 Mar 5;966:176372. (IF= 5发表当年),JCR一区(二区top)。